Olivier Morel is Professor of cardiovascular Medicine at the University of Strasbourg, France since 2009 and is the Director of Interventional cardiology Department (Nouvel Hôpital Civil, Strasbourg, France). He received his PhD from University of Paris 7 Denis Diderot (Biology and Pharmacology of Vessels and Hemostasis) in 2007. He is member of the “Regenerative Nanomedicine” laboratory, UMR 1260 Inserm-Unistra, Strasbourg, France.

His main field of expertise are endothelium dysfunction, catecholaminergic cardiomyopathy (Takotsubo Syndrome), atrial fibrillation, anti-platelet therapy and mechanisms of atherothrombosis including senescence and premature ageing. Recent interest was given to transcather aortic valve replacement (TAVR) procedures and the link between flow turbulence, proteolysis of high molecular weight vWF factors, primary hemostatic disorders and the risk of early but also late bleedings.
His fundamental research is focussed on the link between apoptotic cell death and the generation of procoagulant microparticles in the vasculature and the importance of cardiovascular protection during acute injury. More recently, pharmacological approaches enabling the preservation of cardiovascular function including inhibition of endothelial senescence or the prevention of valvular dysfunction were investigated

Pr. Morel has published around 130 papers in peer-reviewed journals including high impact journals (New Engl J Med, J Am Coll Cardiol, Circulation…) and over 100 communications in his area of expertise (SIGAPS score 2100 points).

Pr Morel is a regular referee for Circulation, Circulation Journal, J Am Coll Cardiol, J Am Coll Cardiol Cardiovasc Interv, Am J Cardiol, Journal of Thrombosis and Haemostasis, Thrombosis and Haemostasis, Atherosclerosis, ATVB, Thrombosis Research, Journal of Clinical medicine.

He serves as the Section Editor-in-Chief (SEiC) “Vascular Medicine” for the Journal of Clinical Medicine (IF 5) from January 2020.

Pr. Morel has received several distinctions of the French Society of Cardiology including the Young Investigator Award in 2004.


Key words: thrombosis, acute coronary syndrome, platelet, chronic kidney disease, senescence, bleedings, aortic stenosis, TAVR, microparticles, endothelium, atrial fibrillation, Takotsubo


Main recent publications

Matsushita K, Marchandot B, Kibler M, Trimaille A, Hess S, Grunebaum L, Reydel A, Jesel L, Ohlmann P, Morel O. P2Y12 Inhibition by Clopidogrel Increases Periprocedural Bleeds in Patients Undergoing Transcatheter Aortic Valve Replacement.J Am Coll Cardiol. 2019 Nov 26;74(21):2707-2708. doi: 10.1016/j.jacc.2019.09.036

Hasan H, Park SH, Auger C, Belcastro E, Matsushita K, Marchandot B, Lee HH, Qureshi AW, Kauffenstein G, Ohlmann P, Schini-Kerth VB, Jesel L, Morel O. Thrombin Induces Angiotensin II-Mediated Senescence in Atrial Endothelial Cells: Impact on Pro-Remodeling Patterns. J Clin Med. 2019 Oct 1;8(10). pii: E1570. doi: 10.3390/jcm8101570.

Jimenez C, Ohana M, Marchandot B, Kibler M, Carmona A, Peillex M, Heger J, Trimaille A, Matsushita K, Reydel A, Hess S, Jesel L, Ohlmann P, Morel O. Impact of Antithrombotic Regimen and Platelet Inhibition Extent on Leaflet Thrombosis Detected by Cardiac MDCT after Transcatheter Aortic Valve Replacement.J Clin Med. 2019 Apr 12;8(4). pii: E506. doi: 10.3390/jcm8040506

Kibler M, Marchandot B, Messas N, Labreuche J, Vincent F, Grunebaum L, Hoang VA, Reydel A, Crimizade U, Kindo M, Hoang MT, Zeyons F, Trinh A, Petit-Eisenmann H, De Poli F, Leddet P, Duhamel A, Jesel L, Ohana M, Susen S, Ohlmann P, Van Belle E, Morel O. Primary Hemostatic Disorders and Late Major Bleeding After Transcatheter Aortic Valve Replacement. J Am Coll Cardiol. 2018 Oct 30;72(18):2139-2148. doi: 10.1016/j.jacc.2018.08.2143.

Marchandot B, Kibler M, Charles AL, Trinh A, Eisenmann HP, Zeyons F, Von Hunolstein JJ, Reydel A, Matsushita K, Kindo M, Hoang Minh T, Leddet P, De Poli F, Messas N, Jesel L, Ohlmann P, Geny B, Morel O. Does Transcatheter Aortic Valve Replacement Modulate the Kinetic of Superoxide Anion Generation? Antioxid Redox Signal. 2019 Jan 31. doi: 10.1089/ars.2018.7689.

Jesel L, Berthon C, Messas N, Lim HS, Girardey M, Marzak H, Marchandot B, Trinh A, Ohlmann P, Morel O. Ventricular arrhythmias and sudden cardiac arrest in Takotsubo cardiomyopathy: Incidence, predictive factors, and clinical implications. Heart Rhythm. 2018 Apr 6. pii: S1547-5271(18)30341-2. doi: 10.1016/j.hrthm.2018.04.002. [Epub ahead of print].

Abbas M, Jesel L, Auger C, Amoura L, Messas N, Manin G, Rumig C, León-González AJ, Ribeiro TP, Silva GC, Abou-Merhi R, Hamade E, Hecker M, Georg Y, Chakfe N, Ohlmann P, Schini-Kerth VB, Toti F, Morel O. Endothelial Microparticles From Acute Coronary Syndrome Patients Induce Premature Coronary Artery Endothelial Cell Aging and Thrombogenicity: Role of the Ang II/AT1 Receptor/NADPH Oxidase-Mediated Activation of MAPKs and PI3-Kinase Pathways. Circulation. 2017 Jan 17;135(3):280-296. doi: 10.1161/CIRCULATIONAHA.116.017513.

Cung TT, Morel O, Cayla G, Rioufol G, Garcia-Dorado D, Angoulvant D, Bonnefoy-Cudraz E, Guérin P, Elbaz M, Delarche N, Coste P, Vanzetto G, Metge M, Aupetit JF, Jouve B, Motreff P, Tron C, Labeque JN, Steg PG, Cottin Y, Range G, Clerc J, Claeys MJ, Coussement P, Prunier F, Moulin F, Roth O, Belle L, Dubois P, Barragan P, Gilard M, Piot C, Colin P, De Poli F, Morice MC, Ider O, Dubois-Randé JL, Unterseeh T, Le Breton H, Béard T, Blanchard D, Grollier G, Malquarti V, Staat P, Sudre A, Elmer E, Hansson MJ, Bergerot C, Boussaha I, Jossan C, Derumeaux G, Mewton N, Ovize M. Cyclosporine before PCI in Patients with Acute Myocardial Infarction. N Engl J Med. 2015 Sep 10;373(11):1021-31. doi: 10.1056/NEJMoa1505489. Epub 2015 Aug 30.