Topic 7 – Biogalenic and Therapeutic Innovations


The general objective of the Biogalenic and Therapeutic Innovations team is to develop new systems both for therapy or tissue engineering and for diagnosis, achieved through different techniques and innovative formulations containing molecules of interest, or the development of functional systems.

Multidisciplinary, the Biogalenic and Therapeutic Innovations team covers many scientific fields such as formulation, chemical modification, processes, nanosciences, and the science of semi-solid and solid materials. It also benefits from the know-how of the other teams of the Regenerative Nanomedicine laboratory as well as the CRBS technology platforms.


Scientific expertise

  • Formulations design and development
    • Emulsions
    • Dry dosage forms
    • Innovative drug delivery systems
  • Smart nanotechnologies
    • Biopharmacy
    • Drug Targeting
    • Medical imaging and theranostic
  • Stimuli-responsive Biomaterials
    • Natural and synthetic polymers
    • Synthesis, formulation and evaluation

Technical expertise

  • Dissolution and drug release profiles
    • Continuous flow
    • Spectrometry UV-Vis, Fluorescence
  • Physical-chemistry of particles, nanoparticles and interfaces
    • Granulometry
    • Drop tensiometry and interfacial rheology
    • Characterization of nanoparticles surface properties
  • Chemistry and formulation
    • Polymer synthesis
    • Chemical functionnalization
    • Nano-emulsification by spontaneous and high-energy methods
    • Optical microscopy
    • Freeze-drying
  • Characterization of the formulations and materials
    • Oscillatory rheology
    • Stability studies

Let’s meet up !

Always on the lookout for new partners and new fields of application, the Biogalenic and Therapeutic Innovations team will welcome you to support you in your projects or jointly develop and characterize new innovative systems.


Team members of Topic 7




Full Professor (CE2)

+33 (0)3 68 85 41 06

Nicolas ANTON

Associate Professor (HDR, HC)

+33 (0)3 68 85 42 51

Guillaume CONZATTI

Associate Professor

+33 (0)3 68 85 43 05

Abedalaziz ABBARA

PhD Student


PhD Student

Publications of Topic 7


  • Pharmaceutics, 2021, 13(7), 1030.
    Water-in-oil nano-emulsions prepared by spontaneous emulsification: new insights on the formulation process.
    Akram, S.; Anton, N.; Omran, Z.*; Vandamme, T.F.*
  • Nanomaterials, 2021, 11(3), 826.
    Ultrabright Green-Emitting Nanoemulsions Based on Natural Lipids-BODIPY Conjugates
    Wang, X.; Bou, S.; Klymchenko, A.S.; Anton, N.*; Collot, M.*
  • Nano Select, 2021, 2(5), 948-957.
    Programming of drug release via rolling-up of patterned biopolymer films
    Pedron, R.; Vandamme, T.F.; Luchnikov, V.A.*
  • International Journal of Pharmaceutics, 2021, 605, 120810.
    Characterization of a hyaluronic acid-based hydrogel containing an extracellular oxygen carrier (M101) for periodontitis treatment : An in vitro study
    Özçelik, H.; Batool, F.; Corre, M.; Garlaschelli, A.; Conzatti, G.; Stutz, C.; Petit, C.; Delpy, E.; Zal, F.; Leize-Zal, E.; Huck, O.*
  • ACS Applied Nano Materials, 2021, 4(5), 5319-5329.
    Controlled Synthesis of NaYF4:Yb,Er Upconversion Nanocrystals as Potential Probe for Bioimaging: A Focus on Heat Treatment.
    Kavand, A; Serra, C.A.; Blanck, C.; Lenertz, M.; Anton, N.; Vandamme, T.F.; Mély, Y.; Przybilla, F.; Chan-Seng, D.*
  • Nanomedicine, Nanotechnology, Biology and Medicine, 2021, 34, 102374.
    Fluorescent nanocarriers targeting VCAM-1 for early detection of senescent endothelial cells
    Belcastro, E.; Rehman, A.U.; Remila, L.; Park, S.H.; Gong, D.S.; Anton, N.; Auger, C.; Lefebvre, O.; Goetz, J.G.; Collot, M.; Klymchenko, A.S.; Vandamme, T.F.; Schini-Kerth, V.B.*
  • Langmuir, 2021, 37(8), 2586-2595.
    The pH-induced specific area changes of unsaturated lipids deposited onto a bubble interface
    Anton, N.*; Pierrat, P.; Brou, G.; Gbassi, G.; Omran, Z.; Lebeau, L.; Vandamme, T.F.; Bouriat, P.*
  • Soft Matter, 2021, 17, 1788-1795.
    Tunable Functionalization of Nano-emulsions Using Amphiphilic Polymers
    Rehman, A.U.; Anton, N.*; Bou, S.; Schild, J.; Messaddeq, N.; Vandamme, T.F.; Akram, S.; Klymchenko, A.; Collot, M.*
  • Angewandte Chemie Int. Ed., 2021, 60(12), 6573-6580.
    Drug‐sponge lipid nanocarrier for in situ cargo loading and release using dynamic covalent chemistry
    Liu, F.; Niko, Y.; Bouchaala, R.; Mercier, L.; Lefebvre, O.; Andreiuk, B.; Vandamme, T.; Goetz, J.G.; Anton, N.; Klymchenko, A.S.*
  • ChemBioChem, 2021, 22(4), 657-661.
    Self-organization properties of a GPCR binding peptide incorporating fluorinated tail studied by fluorine NMR
    Jourdain de Muizon, C.; Ramanoudjame, S.M.; Esteoulle, L.; Ling, C.; Brou, G.; Anton, N.; Vandamme, T.F.; Delsuc, M.A.; Bonnet, D.*; Kieffer, B.*
  • Advanced Healthcare Materials, 2021, 10(1); 2001289.
    Dye-loaded nanoemulsions: biomimetic fluorescent nanocarriers for bioimaging and nanomedicine
    Klymchenko, A.S.*; Liu, F.; Collot, M.; Anton, N.


  • European Polymer Journal, 2020, 137, 109935.
    Tuning polymers grafted on upconversion nanoparticles for the delivery of 5-fluorouracil
    Kavand, A.; Anton, N.; Vandamme, T.; Serra, C.A.; Chan-Seng, D.*
  • Evidence-Based Complementary and Alternative Medicine (eCAM), 2020, vol. 2020, 6976973
    Evaluation of Antimicrobial Activity of Triphala Constituents and Nanoformulation
    Omran, Z.; Bader, A.; Porta, A.; Vandamme, T.; Anton, N.; Alehaideb, Z.; El-Said, H.; Faidah, H.; Essa, A.; Vassallo, A.*; Halwani, M.*
  • Polymer Chemistry, 2020, 11, 4313-4325.
    Investigating the growth of hyperbranched polymers by self-condensing vinyl RAFT copolymerization from the surface of upconversion nanoparticles
    Kavand, A.; Blanck, C.; Przybilla, F.; Mély, Y.; Anton, N.; Vandamme, T.F.; Serra, C.A.; Chan-Seng D.*
  • Journal of Colloid and Interface Science, 2020, 578, 768-778.
    Further insights into release mechanisms from nano-emulsions, assessed by a simple fluorescence-based method
    Wang, X.; Collot, M.; Omran, Z.; Vandamme, T.F.; Klymchenko, A.; Anton, N.*
  • International Journal of Pharmaceutics, 2020, 586, 119534.
    Development of a thermosensitive statin loaded chitosan-based hydrogel promoting bone healing
    Petit, C.; Batool, F.; Stutz, C.; Anton, N.; Klymchenko, A.S.; Vandamme, T.; Benkirane-Jessel, N.; Huck, O.*
  • International Journal of Pharmaceutics, 2020, 585, 119481.
    Production of lipophilic nanogels by spontaneous emulsification
    Ding, S.; Mustafa, B.; Anton, N.*; Serra, C.A.*; Chan-Seng, D.; Vandamme, T.F.*
  • Journal of Materials Chemistry B, 2020, 8, 5938-5944.
    Near infrared fluorogenic probe as a prodrug model for evaluating cargo release by nanoemulsions
    Bou, S.; Wang, X.; Anton, N.; Klymchenko, A.S.; Collot, M.*
  • Soft Matter, 2020, 16, 4173-4181.
    Lipid-Core/Polymer-Shell Hybrid Nanoparticles: Synthesis and Characterization by Fluorescence Labeling and Electrophoresis
    Bou, S.; Wang, X.; Anton, N.; Bouchaala, R. ; Klymchenko, A.S.; Collot, M.*
  • Colloids and Surfaces B: Biointerfaces, 2020, 191, 111010.
    Pickering nano-emulsions stabilized by Eudragit RL100 nanoparticles as oral drug delivery system for poorly soluble drugs
    Dieng, S.M.*; Omran, Z.*; Anton, N.; Thioune, O.; Djiboune, A.R.; Sy, P.M.; Messaddeq, N.; Ennahar, S.; Diarra, M.; Vandamme, T.*
  • Journal of Controlled Release, 2020, 321, 385-311.
    Synthesis and functionalization of hyperbranched polymers for targeted drug delivery
    Kavand, A.; Anton, N.; Vandamme, T.F.; Serra, C.A.; Chan-Seng, D.*


  • Pharmaceutics, 2019, 11(11), 601.
    Synthesis, Principles and Properties of magnetite nanoparticles for in vivo imaging applications – A review
    Wallyn, J.; Anton, N.*; Vandamme, T.F.*
  • Soft Matter, 2019, 15, 8164-8174
    Pickering nano-emulsions stabilized by solid lipid nanoparticles as temperature sensitive drug delivery system
    Dieng, S.M.; Anton, N.*; Bouriat, P.; Thioune, O.; Sy, P.; Messaddeq, N.; Ennahar, S.; Diarra, M.; Vandamme, T.F.*
  • Journal of Pharmacy and Pharmacology, 2019, 71(8), 1185-1198.
    An overview of active and passive targeting strategies to improve the nano-carrier’s efficiency to tumor sites
    Attia, M.F.*; Anton, N.; Wallyn, J.; Omran, Z.H.*; Vandamme, T.F.*
  • Pharmaceutical Research, 2019, 36(6), 78.
    Biomedical imaging: principles, technologies, clinical aspects, contrast agents, limitations and future trends in nanomedicines
    Wallyn, J.; Anton, N.*; Akram, S.; Vandamme, T.F.
  • ACS Applied Materials & Interfaces, 2019, 11(14), 13079-13090.
    Optimizing the Fluorescent Properties of Nano-emulsions for Single Particle Tracking in Live Cells
    Wang, X.; Anton, N.*; Pichandi, A.; Anton, H.; Kyong, F.T.; Vandamme, T.F.; Klymchenko, A.S.*; Collot, M.*
  • Langmuir, 2019, 35(6), 2313-2325.
    Towards the formulation of stable micro and nano double emulsions through silica coating of internal water droplets
    Akram, S.; Wang, X.; Vandamme, T.F.; Collot, M.; Ur Rehman, A.; Messaddeq, N.; Mély, Y.; Anton, N.*
  • Journal of Controlled Release, 2019, 295, 31-49.
    Double emulsions prepared by two-step emulsification: History, State-of-the-art and Perspective
    Ding, S.; Serra, C.A.*; Wei, Y.; Vandamme, T.F.; Anton, N.*
  • ACS Applied Materials & Interfaces, 2019, 11(1), 403-416.
    Magnetite and iodine-containing nano-emulsion as dual modal contrast agent for X-ray/MR Imaging
    Wallyn, J.; Anton, N.*; Mertz, D.; Begin-Colin, S.; Perton, F.; Serra, C.A.; Franconi, F.; Lemaire, L.; Chiper, M.; Libouban, H.; Messaddeq, N.; Anton, H.; Vandamme, T.F.
  • International Journal of Pharmaceutics, 2019, 558, 1-8.
    Production of dry-state ketoprofen-encapsulated PMMA NPs by coupling micromixer-assisted nanoprecipitation and spray drying
    Ding, S.; Serra, C.A.*; Anton, N.*; Yu, W.; Vandamme, T.F.*


  • ACS Omega, 2018, 3(10):14333-14340.
    Quantifying Release from Lipid Nanocarriers by Fluorescence Correlation Spectroscopy
    Bouchaala, R.; Richert, L.; Anton, N.; Vandamme, T.F.; Djabi, S.; Mely, Y.; Klymchenko, A.S.*
  • European Journal of Pharmaceutics and Biopharmaceutics, 2018, 133, 331-338.
    Development of Doxorubicin hydrochloride loaded pH-sensitive liposomes: investigation on the impact of chemical nature of lipids and liposome composition on pH-sensitivity
    Rehman, A.; Omran, Z.; Anton, H.; Mély, M.; Akram, S.; Vandamme, T.F.; Anton, N.*
  • International Journal of Pharmaceutics, 2018, 549(1-2), 299-305.
    Pickering nano-emulsion as a nanocarrier for pH-triggered drug release
    Sy, P.; Anton, N.; Idoux-Gillet, Y.; Dieng, S.; Messaddeq, N.; Ennahar, S.; Diarra, M.; Vandamme, T.*
  • Langmuir, 2018, 34(5), 1981-1991.
    Microfluidic-assisted production of size-controlled superparamagnetic iron oxide nanoparticles-loaded poly(methyl methacrylate) nanohybrids
    Ding, S.; Attia, M.F.; Wallyn, J.; Taddei, C.; Serra, C.A.*; Anton, N.*; Kassem, M.; Schmutz, M.; Er-Rafik, M.; Messaddeq, N.; Collard, A.; Yu, W.; Giordano, M.; Vandamme, T.F.
  • Acta Biomaterialia, 2018, 66, 200-212.
    A new formulation of Poly(MAOTIB) nanoparticles as an efficient contrast agent for in vivo X-ray imaging
    Wallyn, J.; Anton, N.*; Serra, C.A.; Bouquey, M.; Collot, M.; Anton, H.; Weickert, J.L.; Messaddeq, N.; Vandamme, T.
  • Critical Reviews in Therapeutic Drug Carrier Systems, 2018, 35(5), 391-431.
    Inorganic nanoparticles for X-ray computed tomography imaging
    Attia, M.; Wallyn, J. ; Anton, N.*; Vandamme, T.F.*
  • Colloids and Surfaces B : Biointerfaces, 2018, 175, 91-97.
    Elaboration of a thermosensitive smart biomaterial : from the synthesis to the ex vivo bioadhesion evaluation
    Conzatti, G.; Cavalie, S.; Gayet, F.; Torrisani, J.; Carrère, N.; Tourrette, A.*
  • Applied Surface Science, 2018, 467-468, 940-948.
    Thermosensitive PNIPAM grafted alginate / chitosan PEC
    Conzatti, G.; Ayadi, F.; Cavalie, S.; Carrère, N.; Tourrette, A.*
  • European Polymer Journal,, 2018, 105, 434-441.
    Surface functionalization of plasticized chitosan films through PNIPAM grafting via UV and plasma graft polymerization
    Conzatti, G.; Chamary, S.; De Geyter, N.; Cavalie, S.; Morent, R.; Tourrette, A.*


  • Scientific Reports, 2017, 7(1).
    Non-invasive quantitative imaging of hepatocellular carcinoma growth in mice by micro-CT using liver-targeted iodinated nano-emulsions
    Anton, N.*; Parlog, A.; Bou About, G.; Attia, M.F.; Wattenhofer-Donzé, M.; Jacobs, H.; Goncalves da Cruz, I.; Robinet, E.; Sorg, T.; Vandamme T.F.
  • Colloids and Surfaces B: Biointerfaces, 2017, 156, 414-421.
    Light-triggered release from dye-loaded fluorescent lipid nanocarriers in vitro and in vivo
    Bouchaala, R.; Anton, N.; Anton, H.; Vandamme, T.; Mély, Y.; Vermot J.; Smail, D.; Klymchenko, A.S.*
  • Macromolecular Biosciences, 2017, 7(17).
    Functionalizing nano-emulsions with carboxylates: impact on the biodistribution and pharmacokinetics in mice
    Attia, M.F.; Dieng, S.M.; Collot, M.; Klymchenko, A.S.; Bouillot, C.; Serra, C.A.; Schmutz, M.; Er-Rafik, M.; Vandamme, T.F.; Anton, N.*
  • Soft Matter, 2017, 13(8), 1660-1669.
    A new method for the formulation of double nano-emulsions
    Ding, S.; Anton, N.*; Akram, S.; Er-Rafik, M.; Anton, H.; Klymchenko, A.; Yu, W.; Vandamme, T.F.; Serra, C.A.*
  • Petroleum Science and Technology, 2017, 35(11), 1124-1129.
    Tuning of properties of alkyl phenol formaldehyde resins in petroleum demulsifiers. 2. Interfacial dilatational properties
    Velasquez, I.; Anton, N.; Sykora, J.; Pereira, J.*
  • Petroleum Science and Technology, 2017, 35(10), 1055-1062.
    Tuning of properties of alkyl phenol formaldehyde resins in petroleum demulsifiers. 1. Emulsion stability test
    Velasquez, I.; Sykora, J.; Anton, N.; Pereira, J.*
  • Carbohydrate Polymers, 2017, 172, 142-151.
    Alginate/chitosan polyelectrolyte complexes : A comparative study of the influence of the drying step on physicochemical properties
    Conzatti, G.; Faucon, D.; Castel, M.; Ayadi, F.; Cavalie, S.; Tourrette, A.*
  • Colloids and Surfaces B : Biointerfaces, 2017, 151, 143-155.
    PNIPAM grafted surfaces through ATRP and RAFT polymerization : chemistry and bioadhesion
    Conzatti, G.; Cavalie, S.; Combes, C.; Torrisani, J.; Carrère, N.; Tourrette, A.*
  • Journal of Medical and Biological Engineering, 2017, 38, 10–21.
    Influence of Homogenization Technique and Blend Ratio on Chitosan/Alginate Polyelectrolyte Complex Properties
    Castel, M.*; Conzatti, G.; Torrisani, J.; Rouilly, A.; Cavalie, S.; Carrère, N.; Tourrette, A.