Topic 2 – Anti-Inflammatory Therapeutics, Periodontal Regeneration and Dental Engineering

Scientific expertise

  • Development of innovative pharmacological treatment of periodontal and oral bony defects ;
  • Assessment of the pathophysiological processes involved in periodontitis and development of innovative therapies for periodontal regeneration ;
  • Engineering of the dental organ: coronary morphogenesis, vascularization, innervation, eruption, and bone/tooth interactions.

Periodontitis-Induced Mouse Model (O. HUCK)

Periodontitis induced by porphyromonas gyngivalis ligatures

Induction of experimental periodontitis. P. gingivalis infected ligatures were placed along the cervical margins on palatal sides of the maxillary first and second molars as described by Saadi-Thiers et al. J. Periodontol. 84, 396–406 (2013).


Spheroïds

P. gingivalis bypasses the epithelial barrier to reach FBs located at the core of the MT leading to MT destruction. SEM imaging of uninfected MT, and MT infected with P. gingivalis for 24 h. Green arrows indicate P. gingivalis infection in MT and/or cell invasion; blue arrows indicate the disruption of epithelial barrier, multiple apoptotic cells and an acute cellular injury in all strata of the MT – EC and FB-; white arrow indicates proliferating EC at the surface of MT.
Immunofluorescence staining of uninfected MT and infected with P. gingivalis for 24 h (green: APAF-1, red: E-cadherin, blue: DAPI – nuclear staining).

Tooth engineering (S. KUCHLER-BOPP)

Bioengineered tooth (bell stage) preparation and implantation in the maxillary bone. ED14=Embryonic Day, SEM = scanning electronic microscopy.

Vascularization and innervation of the bioengineered tooth

Vascularization and innervation of a bioengineered tooth after subcutaneous implantation in cyclosporin A (CsA)-treated ICR mice.

Histology, vascularization and innervation of bioengineered tooth implanted on PCL scaffolds functionalized with CsA-loaded nanoparticles (chitosan/PLGA/CsA) after four weeks of implantation in maxillary bone.

Bone/tooth interaction and Eruption

Stages of the microsurgery: maxillary bone lesion obtained with a dental bur (500 m), implantation of the PCL membrane with the bioengineered tooth and closing of the gingiva with biological glue. M1 = first molar.

Observation of an erupted bioengineered tooth. Microtomography (µCT, A), 3D reconstruction (B) and histology (C-E, Gomori staining) of a bioengineered tooth implanted with PCL membrane for 10W in the maxillary bone. PDL=periodontal ligament.

Team members of Topic 2

 

Name
Position
Phone
e-mail

Olivier HUCK

PU-PH

 

huck.olivier@gmail.com

Sabine KUCHLER-BOPP

CRHC INSERM

 

kuchler@unistra.fr

Marion STRUB

MCU-PH

 

strub.marion@orange.fr

Catherine PETIT

MCU-PH

 

catherin.petit@gmail.com

Céline STUTZ

PhD Student

 

stutz.celine@gmail.com

Fareeha BATOOL

ATER

 

s_fareeha_b@hotmail.com

Hayriye OZCELIK

Post-doctoral fellow

 

inthecell@gmail.com

Publications of Topic 2

2021

  • Benli M, Batool F, Stutz C, Petit C, Jung S, Huck O. Orofacial manifestations and dental management of systemic lupus erythematosus: A review. Oral Dis. 2021 Mar;27(2):151-167. doi: 10.1111/odi.13271.
  • Gegout PY, Stutz C, Olson J, Batool F, Petit C, Tenenbaum H, Benkirane-Jessel N, Huck O. Adv Exp Med Biol. 2021;1341:67-87. doi: 10.1007/5584_2020_593.
  • Benli M, Eker Gümüş B, Kahraman Y, Yağcı Ö, Erdoğan D, Huck O, Özcan M.J Thermal, structural and morphological characterization of dental polymers for clinical applications. Prosthodont Res. 2021 Jun 30;65(2):176-185. doi: 10.2186/jpr.JPOR_2019_534.
  • Dubar M, Lizambard M, Delcourt-Debruyne E, Batool F, Huck O, Siepmann F, Agossa K. In-situforming drug-delivery systems for periodontal treatment: current knowledge and perspectives. Biomed Mater. 2021 Oct 4;16(6). doi: 10.1088/1748-605X/ac254c.
  • Petit C, Benezech J, Davideau JL, Hamann V, Tuzin N, Huck O. Consideration of Oral Health and Periodontal Diseases During Pregnancy: Knowledge and Behaviour Among French Pregnant Women. Oral Health Prev Dent. 2021;19(1):33-42. doi: 10.3290/j.ohpd.b875513.
  • Batool F, Özçelik H, Stutz C, Gegout PY, Benkirane-Jessel N, Petit C, Huck O. Modulation of immune-inflammatory responses through surface modifications of biomaterials to promote bone healing and regeneration. J Tissue Eng. 2021 Oct 26;12:20417314211041428. doi: 10.1177/20417314211041428.
  • Dubourg S, Huck O, Jung S.J. Implant-based oral rehabilitation in systemic sclerosis patients: a systematic review. Oral Implantol. 2021 May 4. doi: 10.1563/aaid-joi-D-20-00384.
  • Batool F, Delpy E, Zal F, Leize-Zal E, Huck O. Therapeutic Potential of Hemoglobin Derived from the Marine Worm Arenicola marina (M101): A Literature Review of a Breakthrough Innovation.Mar Drugs. 2021 Jun 29;19(7):376. doi: 10.3390/md19070376.
  • Bugueno IM, Benkirane-Jessel N, Huck O. Innate Implication of Toll/IL-1 receptor domain containing adapters in Porphyromonas gingivalis-induced inflammation. Immun. 2021 May;27(4):324-342. doi: 10.1177/17534259211013087.
  • Harmouche L, Reingewirtz Y, Tuzin N, Lefebvre F, Davideau JL, Huck O. Knowledge and Management of Halitosis in France and Lebanon: A Questionnaire-Based Study. J Clin Med. 2021 Feb 1;10(3):502. doi: 10.3390/jcm10030502.
  • Stutz C, Clauss F, Huck O, Schulz G, Benkirane-Jessel N, Bornert F, Kuchler-Bopp S, Strub M. Eruption of Bioengineered Teeth: A New Approach Based on a Polycaprolactone Biomembrane. Nanomaterials (Basel). 2021 May 17;11(5):1315. doi: 10.3390/nano11051315.
  • Omer-Cihangir R, Baser U, Kucukgergin C, Aykol-Sahin G, Huck O, Yalcin F. Int Impact of Smoking on Neutrophil Enzyme Levels in Gingivitis: A Case-Control Study. J Environ Res Public Health. 2021 Jul 30;18(15):8075. doi: 10.3390/ijerph18158075.
  • Huck O, Mulhall H, Rubin G, Kizelnik Z, Iyer R, Perpich JD, Haque N, Cani PD, de Vos WM, Amar S. Authors’ Response: « Akkermansia muciniphila reduces Porphyromonas gingivalis induced inflammation and periodontal bone destruction ». J Clin Periodontol. 2021 Nov;48(11):1493-1494. doi: 10.1111/jcpe.13539.
  • Vagia P, Papalou I, Burgy A, Tenenbaum H, Huck O, Davideau JL. Association between periodontitis treatment outcomes and peri-implantitis: A long-term retrospective cohort study. Clin Oral Implants Res. 2021 Jun;32(6):721-731. doi: 10.1111/clr.13741.
  • Martin-Cabezas R, Deschamps-Lenhardt S, Huck O. Optimization of Connective Tissue Graft Length by Graft Splitting: A Case Series. Clin Adv Periodontics. 2021 Sep;11(3):165-170. doi: 10.1002/cap.10175.
  • Petit C, Anadon-Rosinach V, Tuzin N, Davideau JL, Huck O. Influence of Depression and Anxiety on Non-Surgical Periodontal Treatment Outcomes: A 6-Month Prospective Study. Int J Environ Res Public Health. 2021 Sep 6;18(17):9394. doi: 10.3390/ijerph18179394.
  • Benli M, Huck O, Özcan M. Effect of low-level gallium aluminum arsenide laser therapy on the chewing performance and pain perception of patients with systemic lupus erythematosus: A randomized controlled clinical trial. Cranio. 2021 Aug 29:1-10. doi: 10.1080/08869634.2021.1971888.
  • Benli M, Eker-Gümüş B, Kahraman Y, Huck O, Özcan M. Can polylactic acid be a CAD/CAM material for provisional crown restorations in terms of fit and fracture strength? Dent Mater J. 2021 May 29;40(3):772-780. doi: 10.4012/dmj.2020-232.
  • Singh SP, Huck O, Abraham NG, Amar S. Correction: Kavain Reduces Porphyromonas gingivalis-Induced Adipocyte Inflammation: Role of PGC-1α Signaling. J Immunol. 2021 Nov 1;207(9):2387. doi: 10.4049/jimmunol.2100846.
  • Bornert F, Clauss F, Hua G, Idoux-Gillet Y, Keller L, Fernandez De Grado G, Offner D, Smaida R, Wagner Q, Fioretti F, Kuchler-Bopp S, Schulz G, Wenzel W, Gentile L, Risser L, Müller B, Huck O, Benkirane-Jessel N. Mechanistic Illustration: How Newly-Formed Blood Vessels Stopped by the Mineral Blocks of Bone Substitutes Can Be Avoided by Using Innovative Combined Therapeutics. Biomedicines. 2021 Aug 3;9(8):952. doi: 10.3390/biomedicines9080952.
  • Aykol-Sahin G, Arsan B, Altan-Koran SM, Huck O, Baser U. Association between root taper and root proximity of single-rooted teeth with periodontitis: a cone-beam computed tomography based study. Odontology. 2021 Oct 12. doi: 10.1007/s10266-021-00665-6.
  • Özçelik H, Batool F, Corre M, Garlaschelli A, Conzatti G, Stutz C, Petit C, Delpy E, Zal F, Leize-Zal E, Huck O. Characterization of a hyaluronic acid-based hydrogel containing an extracellular oxygen carrier (M101) for periodontitis treatment: An in vitro study. Int J Pharm. 2021 Aug 10;605:120810. doi: 10.1016/j.ijpharm.2021.120810.

2020

  • Kuchler-Bopp S., Mariotte A., Strub M., Po C., De Cauwer A., Schulz G., Van Bellinghen X., Fioretti F., Clauss F., Georgel P., Benkirane-Jessel N., Bornert F. Temporomandibular joint damage in K/BxN arthritic mice. Int. J. Oral Sci., 2020, DOI: 10.1038/s41368-019-0072-z.
  • Stutz C, Batool F, Petit C, Strub M, Kuchler-Bopp S, Benkirane-Jessel N, Huck O. Influence of parathyroid hormone on periodontal healing in animal models: A systematic review. Arch Oral Biol. 2020 Dec;120:104932. doi: 10.1016/j.archoralbio.2020.104932.
  • Mulhall H, DiChiara JM, Deragon M, Iyer R, Huck O, Amar S. Akkermansia muciniphila and Its Pili-Like Protein Amuc_1100 Modulate Macrophage Polarization in Experimental Periodontitis. Infect Immun. 2020 Dec 15;89(1):e00500-20. doi: 10.1128/IAI.00500-20.
  • Benli M, Eker Gümüş B, Kahraman Y, Yağcı Ö, Erdoğan D, Huck O, Özcan M. Thermal, structural and morphological characterization of dental polymers for clinical applications. J Prosthodont Res. 2021 Jun 30;65(2):176-185. doi: 10.2186/jpr.JPOR_2019_534.
  • Stutz C, Strub M, Clauss F, Huck O, Schulz G, Gegout H, Benkirane-Jessel N, Bornert F, Kuchler-Bopp S. A New Polycaprolactone-Based Biomembrane Functionalized with BMP-2 and Stem Cells Improves Maxillary Bone Regeneration. Nanomaterials (Basel). 2020 Sep 8;10(9):1774. doi: 10.3390/nano10091774.
  • Batool F, Stutz C, Petit C, Benkirane-Jessel N, Delpy E, Zal F, Leize-Zal E, Huck O. A therapeutic oxygen carrier isolated from Arenicola marina decreased P.gingivalis induced inflammation and tissue destruction. Sci Rep. 2020 Sep8;10(1):14745. doi: 10.1038/s41598-020-71593-8.
  • Boulaamaim T, Tenenbaum H, Davideau JL, Huck O. Selective Influence of Smoking on Periodontal Treatment Outcomes after 3 Years of Follow-up. Oral Health Prev Dent. 2020 Sep 4;18(1):823-831. doi: 10.3290/j.ohpd.a45087.
  • Benli M, Olson J, Huck O, Özcan M. A novel treatment modality for myogenous temporomandibular disorders using aromatherapy massage with lavender oil: A randomized controlled clinical trial. Cranio. 2020 Sep 5:1-11. doi:10.1080/08869634.2020.1819067. Epub ahead of print. PMID: 32893748.
  • Petit C, Anadon-Rosinach V, Rettig L, Schmidt-Mutter C, Tuzin N, Davideau JL, Huck O. Influence of psychological stress on non-surgical periodontal treatment outcomes in patients with severe chronic periodontitis. J Periodontol. 2021 Feb;92(2):186-195. doi: 10.1002/JPER.20-0105.
  • Courval A, Harmouche L, Mathieu A, Petit C, Huck O, Séverac F, Davideau JL. Impact of Molar Furcations on Photodynamic Therapy Outcomes: A 6-Month Split-Mouth Randomized Clinical Trial. Int J Environ Res Public Health. 2020 Jun 11;17(11):4162. doi: 10.3390/ijerph17114162.
  • Petit C, Batool F, Stutz C, Anton N, Klymchenko A, Vandamme T, Benkirane-Jessel N, Huck O. Development of a thermosensitive statin loaded chitosan-based hydrogel promoting bone healing. Int J Pharm. 2020 Aug 30;586:119534. doi:10.1016/j.ijpharm.2020.119534.
  • Mulhall H, Huck O, Amar S. Porphyromonas gingivalis, a Long-Range Pathogen: Systemic Impact and Therapeutic Implications. Microorganisms. 2020 Jun 9;8(6):869. doi: 10.3390/microorganisms8060869.
  • Bugueno IM, Zobairi El-Ghazouani F, Batool F, El Itawi H, Anglès-Cano E, Benkirane-Jessel N, Toti F, Huck O. Porphyromonas gingivalis triggers the shedding of inflammatory endothelial microvesicles that act as autocrine effectors of endothelial dysfunction. Sci Rep. 2020 Feb 4;10(1):1778. doi: 10.1038/s41598-020-58374-z.
  • Benli M, Eker Gümüş B, Kahraman Y, Huck O, Özcan M. Surface characterization and bonding properties of milled polyetheretherketone dental posts. Odontology. 2020 Oct;108(4):596-606. doi: 10.1007/s10266-020-00484-1.
  • Benli M, Batool F, Stutz C, Petit C, Jung S, Huck O. Orofacial manifestations and dental management of systemic lupus erythematosus: A review. Oral Dis. 2021 Mar;27(2):151-167. doi: 10.1111/odi.13271.
  • Huck O, Mulhall H, Rubin G, Kizelnik Z, Iyer R, Perpich JD, Haque N, Cani PD, de Vos WM, Amar S. Akkermansia muciniphila reduces Porphyromonas gingivalis-induced inflammation and periodontal bone destruction. J Clin Periodontol. 2020 Feb;47(2):202-212. doi: 10.1111/jcpe.13214.
  • Benli M, Eker Gümüş B, Kahraman Y, Gökçen-Rohlig B, Evlioğlu G, Huck O, Özcan M. Surface roughness and wear behavior of occlusal splint materials made of contemporary and high-performance polymers. Odontology. 2020Apr;108(2):240-250. doi: 10.1007/s10266-019-00463-1.
  • Kuchler-Bopp S., Mariotte A., Strub M., Po C., De Cauwer A., Schulz G., Van Bellinghen X., Fioretti F., Clauss F., Georgel P., Benkirane-Jessel N., Bornert F. Temporomandibular joint damage in K/BxN arthritic mice. Int. J. Oral Sci., 2020, DOI: 10.1038/s41368-019-0072-z.
  • Stutz C, Batool F, Petit C, Strub M, Kuchler-Bopp S, Benkirane-Jessel N, Huck O. Influence of parathyroid hormone on periodontal healing in animal models: A systematic review. Arch Oral Biol. 2020 Dec;120:104932. doi: 10.1016/j.archoralbio.2020.104932.
  • Mulhall H, DiChiara JM, Deragon M, Iyer R, Huck O, Amar S. Akkermansia muciniphila and Its Pili-Like Protein Amuc_1100 Modulate Macrophage Polarization in Experimental Periodontitis. Infect Immun. 2020 Dec 15;89(1):e00500-20. doi: 10.1128/IAI.00500-20.
  • Benli M, Eker Gümüş B, Kahraman Y, Yağcı Ö, Erdoğan D, Huck O, Özcan M. Thermal, structural and morphological characterization of dental polymers for clinical applications. J Prosthodont Res. 2021 Jun 30;65(2):176-185. doi: 10.2186/jpr.JPOR_2019_534.
  • Stutz C, Strub M, Clauss F, Huck O, Schulz G, Gegout H, Benkirane-Jessel N, Bornert F, Kuchler-Bopp S. A New Polycaprolactone-Based Biomembrane Functionalized with BMP-2 and Stem Cells Improves Maxillary Bone Regeneration. Nanomaterials (Basel). 2020 Sep 8;10(9):1774. doi: 10.3390/nano10091774.
  • Batool F, Stutz C, Petit C, Benkirane-Jessel N, Delpy E, Zal F, Leize-Zal E, Huck O. A therapeutic oxygen carrier isolated from Arenicola marina decreased P.gingivalis induced inflammation and tissue destruction. Sci Rep. 2020 Sep8;10(1):14745. doi: 10.1038/s41598-020-71593-8.
  • Boulaamaim T, Tenenbaum H, Davideau JL, Huck O. Selective Influence of Smoking on Periodontal Treatment Outcomes after 3 Years of Follow-up. Oral Health Prev Dent. 2020 Sep 4;18(1):823-831. doi: 10.3290/j.ohpd.a45087.
  • Benli M, Olson J, Huck O, Özcan M. A novel treatment modality for myogenous temporomandibular disorders using aromatherapy massage with lavender oil: A randomized controlled clinical trial. Cranio. 2020 Sep 5:1-11. doi:10.1080/08869634.2020.1819067.
  • Petit C, Anadon-Rosinach V, Rettig L, Schmidt-Mutter C, Tuzin N, Davideau JL, Huck O. Influence of psychological stress on non-surgical periodontal treatment outcomes in patients with severe chronic periodontitis. J Periodontol. 2021 Feb;92(2):186-195. doi: 10.1002/JPER.20-0105.
  • Courval A, Harmouche L, Mathieu A, Petit C, Huck O, Séverac F, Davideau JL. Impact of Molar Furcations on Photodynamic Therapy Outcomes: A 6-Month Split-Mouth Randomized Clinical Trial. Int J Environ Res Public Health. 2020 Jun 11;17(11):4162. doi: 10.3390/ijerph17114162.
  • Petit C, Batool F, Stutz C, Anton N, Klymchenko A, Vandamme T, Benkirane-Jessel N, Huck O. Development of a thermosensitive statin loaded chitosan-based hydrogel promoting bone healing. Int J Pharm. 2020 Aug 30;586:119534. doi:10.1016/j.ijpharm.2020.119534
  • Mulhall H, Huck O, Amar S. Porphyromonas gingivalis, a Long-Range Pathogen: Systemic Impact and Therapeutic Implications. Microorganisms. 2020 Jun 9;8(6):869. doi: 10.3390/microorganisms8060869.
  • Bugueno IM, Zobairi El-Ghazouani F, Batool F, El Itawi H, Anglès-Cano E, Benkirane-Jessel N, Toti F, Huck O. Porphyromonas gingivalis triggers the shedding of inflammatory endothelial microvesicles that act as autocrine effectors of endothelial dysfunction. Sci Rep. 2020 Feb 4;10(1):1778. doi: 10.1038/s41598-020-58374-z.
  • Benli M, Eker Gümüş B, Kahraman Y, Huck O, Özcan M. Surface characterization and bonding properties of milled polyetheretherketone dental posts. Odontology. 2020 Oct;108(4):596-606. doi: 10.1007/s10266-020-00484-1.
  • Benli M, Batool F, Stutz C, Petit C, Jung S, Huck O. Orofacial manifestations and dental management of systemic lupus erythematosus: A review. Oral Dis. 2021 Mar;27(2):151-167. doi: 10.1111/odi.13271.
  • Huck O, Mulhall H, Rubin G, Kizelnik Z, Iyer R, Perpich JD, Haque N, Cani PD, de Vos WM, Amar S. Akkermansia muciniphila reduces Porphyromonas gingivalis-induced inflammation and periodontal bone destruction. J Clin Periodontol. 2020 Feb;47(2):202-212. doi: 10.1111/jcpe.13214.
  • Benli M, Eker Gümüş B, Kahraman Y, Gökçen-Rohlig B, Evlioğlu G, Huck O, Özcan M. Surface roughness and wear behavior of occlusal splint materials made of contemporary and high-performance polymers. Odontology. 2020 Apr;108(2):240-250. doi: 10.1007/s10266-019-00463-1.
  • Korah L, Amri N, Bugueno IM, Hotton D, Tenenbaum H, Huck O, Berdal A, Davideau JL. Experimental periodontitis in Msx2 mutant mice induces alveolar bone necrosis. J Periodontol. 2020 May;91(5):693-704. doi: 10.1002/JPER.16-0435.

2019

  • Zein N., Harmouch E., Lutz J.-C., Fernandez De Grado G., Kuchler-Bopp S., Clauss F., Offner D., Hua G., Benkirane-Jessel N., Fioretti F. (2019) Polymer-based instructive scaffolds for endodontic regeneration. Materials, 2019, 12(15): 2347.
  • Benli M, Batool F, Stutz C, Petit C, Jung S, Huck O. Orofacial Manifestations and Dental Management of Systemic Lupus Erythematosus: a review. Oral Dis. 2019 Dec 30. doi: 10.1111/odi.13271.
  • Cloitre A, Halgand B, Sourice S, Caillon J, Huck O, Bugueno IM, Batool F, Guicheux J, Geoffroy V, Lesclous P. IL-36γ is a pivotal inflammatory player in periodontitis-associated bone loss. Sci Rep. 2019 Dec 17;9(1):19257.
  • Lizambard M, Menu T, Fossart M, Bassand C, Agossa K, Huck O, Neut C, Siepmann F. In-situ forming implants for the treatment of periodontal diseases: Simultaneous controlled release of an antiseptic and an anti-inflammatory drug.Int J Pharm. 2019 Dec 15;572:118833.
  • Huck O, Mulhall H, Rubin G, Kizelnik Z, Iyer R, Perpich JD, Haque N, Cani PD, De Vos WM, Amar S. Akkermansia muciniphila reduces Porphyromonas gingivalis-induced inflammation and periodontal bone destruction. J Clin Periodontol. 2020 Feb;47(2):202-212.
  • BENLI M, EKER GÜMÜŞ B, KAHRAMAN Y, GÖKÇEN-ROHLIG B, EVLIOĞLU G, HUCK O, ÖZCAN M. Surface roughness and wear behavior of occlusal splint materials made of contemporary and high-performance polymers. Odontology. 2019 Oct 14.
  • Korah L, Amri N, Bugueno IM, Hotton D, Tenenbaum H, Huck O, Berdal A, Davideau JL. Experimental periodontitis in Msx2 mutant mice induces alveolar bone necrosis. J Periodontol. 2019 Sep 30.
  • Huck O, Han X, Mulhall H, Gumenchuk I, Cai B, Panek J, Iyer R, Amar S. Identification of a Kavain Analog with Efficient Anti-inflammatory Effects. Sci Rep. 2019 Sep 10;9(1):12940.
  • Aguilar A, Zein N, Harmouch E, Hafdi B, Bornert F, Offner D, Clauss F, Fioretti F, Huck O, Benkirane-Jessel N, Hua G. Application of Chitosan in Bone and Dental Engineering. Molecules. 2019 Aug 19;24(16).
  • Le Roch S, Rouche F, Valet F, Bouchard P; Escape Group. European survey on criteria of aesthetics for periodontal evaluation: The ESCAPE study. J Clin Periodontol. 2019 Nov;46(11):1116-1123.
  • Batool F, Agossa K, Lizambard M, Petit C, Bugueno IM, Delcourt-Debruyne E, Benkirane-Jessel N, Tenenbaum H, Siepmann J, Siepmann F, Huck O. In-situ forming implants loaded with chlorhexidine and ibuprofen for periodontal treatment: Proof of concept study in vivo. Int J Pharm. 2019 Oct 5;569:118564.
  • Huck O, Buduneli N, Bravo D. Inflammatory Mediators in Periodontal Pathogenesis. Mediators Inflamm. 2019 Jun 18;2019:2610184.
  • Harmouche L, Courval A, Mathieu A, Petit C, Huck O, Severac F, Davideau JL. Impact of tooth-related factors on photodynamic therapy effectiveness during active periodontal therapy: A 6-months split-mouth randomized clinical trial. Photodiagnosis Photodyn Ther. 2019 Sep;27:167-172.
  • Akcali A, Yildiz MS, Akcali Z, Huck O, Friedmann A. Periodontal condition of patients with Thalassemia Major: A systematic review and meta-analysis. Arch Oral Biol. 2019 Jun;102:113-121.
  • Petit C, Batool F, Bugueno IM, Schwinté P, Benkirane-Jessel N, Huck O. Contribution of Statins towards Periodontal Treatment: A Review. Mediators Inflamm. 2019 Feb 27;2019:6367402.
  • Martín-Cabezas R, Huck O. No evidence to support benefit of 14-day courses of amoxicillin-plus-metronidazole as adjunct to non-surgical periodontal treatment at three months. Evid Based Dent. 2019 Mar;20(1):16-17.
  • Petit C, Schmeltz S, Burgy A, Tenenbaum H, Huck O, Davideau JL. Risk factors associated with long-term outcomes after active and supporting periodontal treatments: impact of various compliance definitions on tooth loss. Clin Oral Investig. 2019 Nov;23(11):4123-4131.
  • Deschamps-Lenhardt S, Martin-Cabezas R, Hannedouche T, Huck O. Association between periodontitis and chronic kidney disease: Systematic review and meta-analysis. Oral Dis. 2019 Mar;25(2):385-402. doi: 10.1111/odi.12834.

2018

  • Strub M., Van Bellinghen X., Idoux-Gillet Y., Fioretti F., Bornert F., Benkirane-Jessel N., Kuchler-Bopp S., Clauss F. Maxillary bone regeneration based on nanoreservoirs functionalized epsilon-polycaprolactone biomembranes in a mouse model of jaw bone lesion. Biomed. Res. Int., 2018, 7380389.
  • Kuchler-Bopp S., Bagnard D., Van-der-Heyden M., Idoux-Gillet Y., Strub M., Gegout H., Lesot H., Benkirane-Jessel N., Keller L. Semaphorin 3A receptor inhibitor as a novel therapeutic to promote innervation of bioengineered teeth. J. Tissue Eng Reg. Med., 2018, 12(4): e2151-e2161.
  • Bugueno I.M., Batool F., Keller L., Kuchler-Bopp S., Benkirane-Jessel N., Huck O. Porphyromonas gingivalis bypass epithelial barrier and modulate fibroblastic inflammatory response in an in vitro 3D spheroid model. Scientific reports., 2018, 8(1): 14914.
  • Batool F., Strub M. Bugueno I.M., Bornert F., Clauss F., Huck O., Kuchler-Bopp S., Benkirane-Jessel N. Periodontal tissues, maxillary jaw bone and tooth regeneration : from animal models analyses to clinical applications. Nanomaterials, 2018, 8(5).
  • Strub M., Keller L., Idoux-Gillet Y., Lesot H., Clauss F., Benkirane-Jessel N., Kuchler-Bopp S. Bone marrow stromal cells promote innervation of bioengineered teeth. J. Dent. Res., 2018, 97(10): 1152-1159.
  • Van Bellinghen X., Idoux-Gillet Y., Pugliano M., Strub M., Bornert F., Clauss F., Keller L., Benkirane-Jessel N., Kuchler-Bopp S., Lutz J.C., Fioretti F. Temporomandidular joint regenerative medicine. Int J Mol Sciences, 2018, 19(2).
  • A. Akcali, Z. Akcali, F. Batool, C. Petit, O. Huck. Are sex steroids hormones influencing periodontal conditions? A systematic review. Current Oral Health Rep 2018 1-6.
  • F. Batool, D.-N. Morand, L. Thomas, I.M. Bugueno, J. Aragon, S. Irusta, N. Benkirane-Jessel, H. Tenenbaum, O. Huck. Synthesis of a Novel Electrospun Polycaprolactone Scaffold Functionalized with Ibuprofen for Periodontal Regeneration: An In Vitro and In Vivo Study. Materials 2018. E580. doi: 10.3390/ma11040580.
  • C. Petit, O. Huck, S. Amar, H. Tenenbaum. Management of localized aggressive periodontitis: a 30-year follow-up. Quintessence Int 2018. 21:1-10.
  • O. Huck, J. You, X. Han, B. Cai, J. Panek, S. Amar. Reduction of Articular and Systemic Inflammation by Kava-241 in Porphyromonas gingivalis-induced Arthritis Murine Model. Infect Immun 2018.
  • S. Singh, O. Huck, N. Abraham, S. Amar. Kavain reduces Porphyromonas gingivalis-induced adipocyte inflammation: role of PGC-1a signaling. J Immunol 2018.

2017

  • Chaddad H., Kuchler-Bopp S., Fuhrmann G., Gegout H., Ubeaud-Sequier G., Schwinté P., Bornert F., Benkirane-Jessel N., Idoux-Gillet Y. Combining 2D angiogenesis and 3D osteosarcoma microtissues to improve vascularization. Exp. Cell Res., 2017, 360: 138-145.
  • Acuna-Mendoza S., Martin S., Kuchler-Bopp S., Ribes S., Thalgott J., Chaussain C., Creuzet S., Lesot H., Lebrin F., Poliard A. A new Wnt1-CRE TomatoRosa embryonic stem cell line : a tool for studying neural crest cell integration capacity. Stem Cells Dev., 2017, 26: 1682-1694.
  • Kuchler-Bopp S., Larrea A., Petry L., Idoux-Gillet Y., Sebastian V., Ferrandon A., Schwinté P., Arruebo M., Benkirane-Jessel N. Promoting bioengineered tooth innervation using nanostructured and hybrid scaffolds. Acta Biomater., 2017, 50: 493-501.
  • O. Huck, J. Al-Hashemi, L. Poidevin, O. Poch, J.-L. Davideau, H. Tenenbaum, S. Amar. Identification and Characterization of miRNA differentially expressed in macrophages exposed to Porphyromonas gingivalis infection. Infect Immun. 2017;85(3).
  • A. Alshammari, J. Patel, J.Al-Hashemi, B. Cai, J. Panek, O. Huck, S. Amar. (2017) Kava-241 reduced periodontal destruction in a collagen antibody primed Porphyromonas gingivalis model of periodontitis. J Clin Periodontol. 44(11):1123-1132.
  • P. Schwinté, A. Mariotte, P. Anand, L. Keller, Y. Idoux-Gillet, O. Huck, F. Fioretti, H. Tenenbaum, P. Georgel, W. Wenzel, S. Irusta, N. Benkirane-Jessel. Anti-inflammatory effect of active nanofibrous polymeric membrane bearing nanocontainers of atorvastatin complexes. Nanomedicine (Lond). 2017 Dec;12(23):2651-2674.
  • I.M. Bugueno, F. Batool, L. Korah, N. Benkirane-Jessel, O. Huck. Porphyromonas gingivalis differentially modulates apoptosome apoptotic peptidase activating factor 1 in epithelial cells and fibroblasts. Am J Pathol. 2017 S0002-9440(17)30714-9.