Group headed by N. Benkirane-Jessel
The programs under progress go from fundamental projects to clinical applications and include physico-chemical, molecular and cellular biology approaches and focus on the transfer of the various concepts towards clinical applications (drug or gene therapy, gene silencing and regenerative nanomedicine). Our scientific activity is at the interface of biotechnology and materials science. A major focus is the study and development of active nano-designed polymers to deliver drugs, DNA, siRNA and engineered growth factors, continuously at controlled rates for prolonged periods of time. Work is in progress in the following areas:
(i) Developing controlled release systems that can be enzymatically triggered to increase release rates;
(ii) Designing engineered materials for right timing delivery from multilayered nanoreservoirs (sustained and sequential release for long-term delivery)
(iii) Studying applications of these nanostructured systems including the development of effective long-term delivery systems for growth factors, anti-cancer drugs, gene therapy and gene silencing;
(iv) Controlled release films and functional surfaces targeting inflammation, and bone metastasis prevention;
(v) Stem cell platforms including controlling growth and differentiation to create tissue and organs (bone-tooth unit regeneration, osteochondral regeneration).
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