I received a PhD of Cellular and Molecular Pharmacology from Strasbourg University in 2003. After postdoctoral positions in Québec (CRCHUL) and Angers (MitoVasc institute), I reached UMR1260 INSERM UNISTRA as GERCA Researcher (Groupe pour l’Enseignement et la Recherche Cardiovasculaire en Alsace). My research work has addressed cellular and molecular mechanisms of cardiovascular diseases focusing on purinergic signaling and specifically on ectonucleotidases (CD39). My work has contributed in particular to delineate the contribution of this pathway/enzyme in microvascular mechanotransduction and hypertension or ectopic calcification and thromboinflammatory manifestations associated to the rare disease pseudoxanthoma elasticum. I am currently involved in translational research projects aiming at identifying molecular determinants of senescence and thrombotic complications associated to aortic valve stenosis.

 

Main publications

Kauffenstein, G., A. Drouin, N. Thorin-Trescases, H. Bachelard, B. Robaye, P. D’Orleans-Juste, F. Marceau, E. Thorin and J. Sevigny (2010). “NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse.” Cardiovasc Res

Kauffenstein, G., C. R. Furstenau, P. D’Orleans-Juste and J. Sevigny (2010). “The ecto-nucleotidase NTPDase1 differentially regulates P2Y1 and P2Y2 receptor-dependent vasorelaxation.” Br J Pharmacol

Kauffenstein, G., I. Laher, K. Matrougui, N. C. Guerineau and D. Henrion (2012). “Emerging role of G protein-coupled receptors in microvascular myogenic tone.” Cardiovasc Res

Bouleti C, Mathivet T, Coqueran B, Serfaty JM, Lesage M, Berland E, Ardidie-Robouant C, Kauffenstein G, Henrion D, Lapergue B, Mazighi M, Duyckaerts C, Thurston G, Valenzuela DM, Murphy AJ, Yancopoulos GD, Monnot C, Margaill I, Germain S (2013). ” Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke.” Eur Heart J

Kauffenstein, G., A. Pizard, Y. Le Corre, E. Vessieres, L. Grimaud, B. Toutain, C. Labat, Y. Mauras, T. G. Gorgels, A. A. Bergen, O. Le Saux, P. Lacolley, G. Leftheriotis, D. Henrion and L. Martin (2014). “Disseminated arterial calcification and enhanced myogenic response are associated with abcc6 deficiency in a mouse model of pseudoxanthoma elasticum.” Arterioscler Thromb Vasc Biol

d’Almeida, S. M., G. Kauffenstein, C. Roy, L. Basset, L. Papargyris, D. Henrion, V. Catros, N. Ifrah, P. Descamps, A. Croue, P. Jeannin, M. Gregoire, Y. Delneste and J. Tabiasco (2016). “The ecto-ATPDase CD39 is involved in the acquisition of the immunoregulatory phenotype by M-CSF-macrophages and ovarian cancer tumor-associated macrophages: Regulatory role of IL-27.” Oncoimmunology

Kauffenstein, G., S. Tamareille, F. Prunier, C. Roy, A. Ayer, B. Toutain, M. Billaud, B. E. Isakson, L. Grimaud, L. Loufrani, P. Rousseau, P. Abraham, V. Procaccio, H. Monyer, C. de Wit, J. M. Boeynaems, B. Robaye, B. R. Kwak and D. Henrion (2016). “Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone.” Arterioscler Thromb Vasc Biol

Roy, C., J. Tabiasco, A. Caillon, Y. Delneste, J. Merot, J. Favre, A. L. Guihot, L. Martin, D. C. Nascimento, B. Ryffel, S. C. Robson, J. Sevigny, D. Henrion and G. Kauffenstein (2017). “Loss of vascular expression of nucleoside triphosphate diphosphohydrolase-1/CD39 in hypertension.” Purinergic Signal

Kauffenstein, G., G. G. Yegutkin, S. Khiati, V. Pomozi, O. Le Saux, G. Leftheriotis, G. Lenaers, D. Henrion and L. Martin (2018). “Alteration of Extracellular Nucleotide Metabolism in Pseudoxanthoma Elasticum.” J Invest Dermatol

Omarjee, L., C. Roy, C. Leboeuf, J. Favre, D. Henrion, G. Mahe, G. Leftheriotis, L. Martin, A. Janin and G. Kauffenstein (2019). “Evidence of Cardiovascular Calcification and Fibrosis in Pseudoxanthoma Elasticum Mouse Models Subjected to DOCA-Salt Hypertension.” Sci Rep

Hasan H, Park SH, Auger C, Belcastro E, Matsushita K, Marchandot B, Lee HH, Qureshi AW, Kauffenstein G, Ohlmann P, Schini-Kerth VB, Jesel L, Morel O (2019)” Thrombin Induces Angiotensin II-Mediated Senescence in Atrial Endothelial Cells: Impact on Pro-Remodeling Patterns.” J Clin Med